Morita-Baylis-Hillman adduct 2-(3-hydroxy-2-oxoindolin-3-yl)acrylonitrile (ISACN) modulates the inflammatory process during LPS-induced acute lung injury.

Juliane Santos de França da SilvaDeyse Cristina Madruga CarvalhoLuiz Henrique Agra Cavalcante-SilvaÉssia de Almeida LimaJosé Marreiro de Sales-NetoLarissa Adilis Maria Paiva FerreiraTayná Rodrigues OlegárioRhuan Karlos Santos MendesAline Portantiolo LettninAna Paula de Souza VottoMário Luiz Araújo de Almeida VasconcellosClaudio Gabriel Lima-JuniorSandra Rodrigues-Mascarenhas

Published in: Immunopharmacology and immunotoxicology (2023)

Thus, this work showed for the first time the immunomodulatory action of MBHA in LPS-induced acute lung injury and provided new evidence for the mechanisms related to the anti-inflammatory effect of ISACN.

Keyphrases

lps induced
inflammatory response
anti inflammatory
lipopolysaccharide induced
oxidative stress