Impaired sleep-dependent memory consolidation predicted by reduced sleep spindles in Rolandic epilepsy.

Hunki KwonDhinakaran M ChinappenElizabeth A KinardSkyler K GoodmanJonathan F HuangErin D BerjaKatherine G WalshWen ShiDara S ManoachMark A KramerCatherine J Chu

Published in: bioRxiv : the preprint server for biology (2024)

Children with Rolandic epilepsy have a sleep spindle deficit during the active period of disease which predicts deficits in sleep dependent memory consolidation. This finding provides a mechanism and noninvasive biomarker to aid diagnosis and therapeutic discovery for cognitive dysfunction in Rolandic epilepsy and related sleep activated epilepsy syndromes.

Keyphrases

sleep quality
physical activity
young adults
working memory
small molecule
depressive symptoms
single cell