Chemical genetic interactions elucidate pathways controlling tuberculosis antibiotic efficacy during infection.

Peter O OluochEun-Ik KohMegan M Proulx Charlotte J Reames Kadamba G Papavinasasundaram Kenan C MurphyMatthew D ZimmermanVeronique Anne Dartois Christopher M Sassetti

Published in: bioRxiv : the preprint server for biology (2024)

. Synergistic CGIs comprised distinct metabolic pathways mediating antibiotic efficacy, revealing novel drug mechanisms of action, and defining potential drug targets that would synergize with frontline antitubercular drugs.

Keyphrases

adverse drug
mycobacterium tuberculosis
drug induced
genome wide
emergency department
gene expression
hiv aids
pulmonary tuberculosis
dna methylation