Dysregulation of Metabolic Pathways in Circulating Natural Killer Cells Isolated from Inflammatory Bowel Disease Patients.

Vanessa Zaiatz BittencourtFiona JonesMiriam TosettoGlen A DohertyElizabeth J Ryan

Published in: Journal of Crohn's & colitis (2021)

Our results demonstrate that circulating NK cells of IBD patients have an unbalanced metabolic profile, with faulty mitochondria and reduced capacity to kill. These aberrations in NK cell metabolism may contribute to defective killing and thus the secondary infections and increased risk of cancer observed in IBD patients.

Keyphrases

end stage renal disease
newly diagnosed
nk cells
ejection fraction
squamous cell carcinoma
cell death
dna methylation
copy number