Orexin A alleviates neuroinflammation via OXR2/CaMKKβ/AMPK signaling pathway after ICH in mice.
Tao LiWeilin XuJinsong OuyangXiaoyang LuPrativa SherchanCameron LenahanGiselle IrioJohn H ZhangJianhua ZhaoYongfa ZhangJi-Ping TangPublished in: Journal of neuroinflammation (2020)
OXA improved neurofunctional outcomes and mitigated brain edema after ICH, possibly through alleviating neuroinflammation via OXR2/CaMKKβ/AMPK pathway.
Keyphrases
- cerebral ischemia
- signaling pathway
- lipopolysaccharide induced
- lps induced
- skeletal muscle
- traumatic brain injury
- cognitive impairment
- protein kinase
- pi k akt
- white matter
- subarachnoid hemorrhage
- acinetobacter baumannii
- high fat diet induced
- klebsiella pneumoniae
- resting state
- epithelial mesenchymal transition
- inflammatory response
- blood brain barrier
- brain injury
- mouse model
- escherichia coli
- induced apoptosis
- insulin resistance
- functional connectivity
- multidrug resistant
- pseudomonas aeruginosa
- drug resistant
- multiple sclerosis
- endoplasmic reticulum stress
- weight loss