Dose-dependent benefits of iron-magnetic nanoparticle-coated human umbilical-derived mesenchymal stem cell treatment in rat intracranial hemorrhage model.
Kuan-Hung ChenHan-Tan ChaiKun-Chen LinJohn Y ChiangPei-Hsun SungChih-Hung ChenHon-Kan YipPublished in: Stem cell research & therapy (2022)
Two doses of hUC-MSCs were superior to just one dose for protecting the brain against ICH-induced damage and Ir-MNa-coated hUC-MSCs offered a well adopted method for tracking hUC-MSCs homing into the brain.
Keyphrases
- mesenchymal stem cells
- umbilical cord
- resting state
- white matter
- oxidative stress
- bone marrow
- functional connectivity
- diabetic rats
- high glucose
- cell therapy
- cerebral ischemia
- stem cells
- molecularly imprinted
- drug induced
- multiple sclerosis
- combination therapy
- optic nerve
- mass spectrometry
- subarachnoid hemorrhage
- endothelial cells
- iron deficiency
- solid phase extraction