Pharmacokinetics, clinical efficacy and safety of acetaminophen (paracetamol) in adult horses with naturally occurring chronic lameness.
Melissa A MercerJennifer L DavisHarold C McKenzieChristopher R ByronMaureen E KelleherLauren TragerThomas E CecereKatie E WilsonR M Council-TrocheStephen R WerrePublished in: Equine veterinary journal (2023)
In horses with naturally occurring chronic lameness, acetaminophen at 30 mg/kg produced a transient improvement in subjective lameness and BMIS evaluation. Acetaminophen may not be effective as a monotherapy. Acetaminophen was safe following 21 days of 30 mg/kg PO every 12 h, with no evidence of clinically significant changes in clinicopathological analysis, hepatic biopsy or gastric ulceration scores.