Crinecerfont, a CRF1 Receptor Antagonist, Lowers Adrenal Androgens in Adolescents with Congenital Adrenal Hyperplasia.
Ron S NewfieldKyriakie SarafoglouPatricia Y FechnerNatalie J NokoffRichard J AuchusMaria G VogiatziGeorge S JehaNagdeep GiriEiry RobertsJulia SturgeonJean L ChanRobert H FarberPublished in: The Journal of clinical endocrinology and metabolism (2023)
Adolescents with classic 21OHD CAH had substantial reductions in adrenal androgens and androgen precursors after 14 days of oral crinecerfont administration. These results are consistent with a study of crinecerfont in adults with classic 21OHD CAH.
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