An artificial protein-probe hybrid as a responsive probe for ratiometric detection and imaging of hydrogen peroxide in cells.

Xing ZhangYouxin Fu Guangren Qian Run Zhang Zhi Ping Gordon Xu

Published in: Journal of materials chemistry. B (2021)

An artificial protein-probe hybrid, Cm-Np-B@BSA, was prepared via host-guest interactions between hydrogen peroxide (H2O2)-responsive Cm-Np-B molecule and bovine serum albumin (BSA). The Cm-Np-B@BSA probe exhibited high sensitivity and selectivity towards H2O2 under physiological conditions and had excellent biocompatibility, allowing for sensitive ratiometric detection and imaging of endogenous H2O2 in live cells.

Keyphrases

hydrogen peroxide
living cells
quantum dots
nitric oxide
induced apoptosis
fluorescent probe
cell cycle arrest
cancer therapy
loop mediated isothermal amplification
endoplasmic reticulum stress
single molecule
protein protein
drug delivery
oxidative stress
sensitive detection
mass spectrometry
fluorescence imaging