Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer.

Stefano Marastoni Ainhoa Madariaga Aleksandra PesicSree Narayanan NairZhu Juan LiZvi ShalevTroy KetelaIlaria ColomboVictoria MandilarasMichael CabaneroJeffrey P BruceXuan LiSwati GargLisa WangEric X ChenSarbjot GillNeesha C DhaniWenjiang ZhangMelania PintilieValerie BoweringMarianne KoritzinskyRobert RottapelBradly G Wouters Amit M Oza Anthony M JoshuaStephanie Lheureux

Published in: Cancer research communications (2022)

The combination of the antifungal drug itraconazole with antimalarial drug hydroxychloroquine leads to a cytotoxic lysosomal dysfunction, supporting the rational for further research on lysosomal targeting in ovarian cancer.

Keyphrases

oxidative stress
adverse drug
drug induced
drug delivery
electronic health record