Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer.
Stefano MarastoniAinhoa MadariagaAleksandra PesicSree Narayanan NairZhu Juan LiZvi ShalevTroy KetelaIlaria ColomboVictoria MandilarasMichael CabaneroJeffrey P BruceXuan LiSwati GargLisa WangEric X ChenSarbjot GillNeesha C DhaniWenjiang ZhangMelania PintilieValerie BoweringMarianne KoritzinskyRobert RottapelBradly G WoutersAmit M OzaAnthony M JoshuaStephanie LheureuxPublished in: Cancer research communications (2022)
The combination of the antifungal drug itraconazole with antimalarial drug hydroxychloroquine leads to a cytotoxic lysosomal dysfunction, supporting the rational for further research on lysosomal targeting in ovarian cancer.