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Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer.

Stefano MarastoniAinhoa MadariagaAleksandra PesicSree Narayanan NairZhu Juan LiZvi ShalevTroy KetelaIlaria ColomboVictoria MandilarasMichael CabaneroJeffrey P BruceXuan LiSwati GargLisa WangEric X ChenSarbjot GillNeesha C DhaniWenjiang ZhangMelania PintilieValerie BoweringMarianne KoritzinskyRobert RottapelBradly G WoutersAmit M OzaAnthony M JoshuaStephanie Lheureux
Published in: Cancer research communications (2022)
The combination of the antifungal drug itraconazole with antimalarial drug hydroxychloroquine leads to a cytotoxic lysosomal dysfunction, supporting the rational for further research on lysosomal targeting in ovarian cancer.
Keyphrases
  • oxidative stress
  • adverse drug
  • drug induced
  • drug delivery
  • electronic health record