FleQ DNA Binding Consensus Sequence Revealed by Studies of FleQ-Dependent Regulation of Biofilm Gene Expression in Pseudomonas aeruginosa.
Claudine BaraquetCaroline S HarwoodPublished in: Journal of bacteriology (2015)
The transcription factor FleQ is widely distributed in Pseudomonas species. In all species examined, it is a master regulator of flagellar gene expression. It also regulates diverse genes involved in biofilm formation in P. aeruginosa when intracellular levels of the second messenger c-di-GMP are high. Unlike flagellar genes, biofilm-associated genes are not always easy to recognize in genome sequences. Here, we identified a consensus DNA binding sequence for FleQ. This allowed us to survey Pseudomonas strains and find new genes that are likely regulated by FleQ and possibly involved in biofilm formation.
Keyphrases
- biofilm formation
- dna binding
- pseudomonas aeruginosa
- transcription factor
- gene expression
- genome wide identification
- candida albicans
- staphylococcus aureus
- genome wide
- escherichia coli
- dna methylation
- cystic fibrosis
- acinetobacter baumannii
- bioinformatics analysis
- genome wide analysis
- clinical practice
- drug resistant