Association Between Adrenal-Restrictive HSD3B1 Inheritance and Hormone-Independent Subtypes of Endometrial and Breast Cancer.

Jeffrey M McManusRoberto VargasPeter S BazeleyFredrick R SchumacherNima Sharifi

Published in: JNCI cancer spectrum (2022)

These findings suggest roles for adrenal-restrictive vs adrenal-permissive steroidogenesis, by way of rs1047303 genotype, in the development of and/or outcomes from at least 3 commonly hormone-associated types of cancer: prostate, breast, and endometrial.

Keyphrases

prostate cancer
papillary thyroid
endometrial cancer
mitochondrial dna
squamous cell carcinoma
gene expression
young adults
lymph node metastasis
genome wide
breast cancer risk