More than just inflammation: Ureaplasma species induce apoptosis in human brain microvascular endothelial cells.

Christine SilwedelAxel HaarmannMarkus FehrholzHeike ClausChristian P SpeerKirsten Glaser

Published in: Journal of neuroinflammation (2019)

By inducing apoptosis in HBMEC as main constituents of the blood-brain barrier, Ureaplasma spp. may provoke barrier breakdown. Simultaneous suppression of inflammatory cell death may additionally attenuate host defense strategies. Ultimate consequence could be invasive and long-term CNS infections by Ureaplasma spp.

Keyphrases

cell death
oxidative stress
cell cycle arrest
endothelial cells
endoplasmic reticulum stress
pi k akt
blood brain barrier
high glucose
genetic diversity
essential oil