Coordinated inhibition of C/EBP by Tribbles in multiple tissues is essential for Caenorhabditis elegans development.
Kyung Won KimNishant ThakurChristopher A PiggottShizue OmiJolanta PolanowskaYishi JinNathalie PujolPublished in: BMC biology (2016)
Together, our data uncover an unprecedented crosstalk involving multiple tissues, in which NIPI-3 acts as a master regulator to inhibit CEBP-1 and the PMK-1/p38 MAPK pathway. In doing so, it keeps innate immunity in check and ensures proper organismal development.