Identification of a CEACAM5 targeted nanobody for positron emission tomography imaging and near-infrared fluorescence imaging of colorectal cancer.
Yitai XiaoChaoming MeiDuo XuFan YangMeilin YangLei BiJunjie MaoPengfei PangDan LiPublished in: European journal of nuclear medicine and molecular imaging (2023)
Collectively, we presented the identification and in vivo validation of a CEACAM5-targeted nanobody and a fused nanobody with an ABD, which enabled to the non-invasive visualization of malignancy of CRC using PET imaging and NIR imaging in subcutaneous models as well as LNM models.