Alcohol and colorectal cancer risk, subclassified by mutational signatures of DNA mismatch repair deficiency.
Ai-Ping FangTomotaka UgaiCarino GurjaoRong ZhongZhenhua LiuXinyuan ZhangPeilu WangJonathan NowakMolin WangMarios GiannakisShuji OginoXuehong ZhangEdward L GiovannucciPublished in: Journal of the National Cancer Institute (2024)
High alcohol consumption was associated with an increased incidence of CRC containing higher contributions of c-dMMRb/SBS26, suggesting that alcohol consumption may be involved in colorectal carcinogenesis through the DNA mismatch repair pathway.