Cucurbit[7]uril-Based Supramolecular DNA Nanogel for Targeted Codelivery of Chemo/Photodynamic Drugs.
Hai YangZongze DuanFengbo LiuZhiyong ZhaoSi-Min LiuPublished in: ACS macro letters (2023)
Nanodrug delivery systems for the delivery of combination therapeutics have shown their exceptionally potential clinical application by facilitating better synergistic anticancer effects. Herein, we developed a universal strategy to fabricate supramolecular DNA nanogels from DNA tetrahedron skeleton and cucurbit[7]uril-based host-guest interaction for codelivery the chemo and photodynamic therapy drugs. The constructed supramolecular DNA nanogels showed the size tunability, host-guest competition and DNA enzyme responsibility. The cell uptake and MTT experiments demonstrated that the nanogel has excellent biocompatibility and specificity, and achieved the enrichment and slow release of drug in cells. Finally, the combined chemo/photodynamic therapy was realized by coloading doxorubicin hydrochloride and methylene blue. It was proven to be a better stragety to promote apoptosis of cancer cells compared to single chemotherapy or photodynamic therapy. These results suggest that our proposed supramolecular nanogels have provided an effective nanoplatform for drug delivery in the combinational therapy for cancer.
Keyphrases
- photodynamic therapy
- cancer therapy
- circulating tumor
- drug delivery
- cell free
- fluorescence imaging
- single molecule
- water soluble
- cell cycle arrest
- energy transfer
- nucleic acid
- oxidative stress
- locally advanced
- single cell
- cell death
- bone marrow
- cell therapy
- cell proliferation
- young adults
- mesenchymal stem cells
- papillary thyroid
- quantum dots