Fluvastatin promotes chondrogenic differentiation of adipose-derived mesenchymal stem cells by inducing bone morphogenetic protein 2.

Masanari KuwaharaYukio AkasakiNorio GotoIchiro KurakazuTakuya SueishiMasakazu ToyaTaisuke UchidaTomoaki TsutsuiRyota HiroseHidetoshi TsushimaYasuharu Nakashima

Published in: BMC pharmacology & toxicology (2022)

Our results suggest that fluvastatin promotes chondrogenic differentiation of hADMSCs by inducing endogenous BMP2, and that one of the mechanisms underlying the effects is inhibition of RhoA-ROCK signaling via suppression of GGPP. Fluvastatin is a safe and low-cost compound that holds promise for use in transplantation of hADMSCs for cartilage regeneration.

Keyphrases

low cost
mesenchymal stem cells
stem cells
adipose tissue
cell therapy
insulin resistance
big data
artificial intelligence