Tumor-derived ILT4 induces T cell senescence and suppresses tumor immunity.

Aiqin GaoXia LiuWenli LinJingnan WangShuyun WangFusheng SiLan HuangYangjing ZhaoYuping SunGuangyong Peng

Published in: Journal for immunotherapy of cancer (2021)

These studies identify a novel mechanism responsible for ILT4-mediated immune suppression in the tumor microenvironment, and prove a novel concept of ILT4 as a critical checkpoint molecule for tumor immunotherapy.

Keyphrases

dna damage
signaling pathway
endothelial cells
cell cycle
oxidative stress
case control