Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C.

Hong ZhangShi-Hui ZhangJia-Li HuYu-Tong WuXiao-Yan MaYang ChenBing YuShuang LiaoHuilin Huang Song Gao

Published in: Cancer communications (London, England) (2021)

FAM46C is a prokaryotic-like PAP with preference for A-rich RNA substrates, and showed distinct enzymatic efficiency with its homolog FAM46B. The MM-related missense mutations of FAM46C lead to various structural and biochemical outcomes to the protein.

Keyphrases

multiple myeloma
type diabetes
nitric oxide
skeletal muscle
nucleic acid