Obesity and its impact on COVID-19.
Angélica J M de LeeuwMaureen A M Oude LuttikhuisAnnemarijn C WellenChristine MüllerCornelis F CalkhovenPublished in: Journal of molecular medicine (Berlin, Germany) (2021)
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic has proven a challenge to healthcare systems since its first appearance in late 2019. The global spread and devastating effects of coronavirus disease 2019 (COVID-19) on patients have resulted in countless studies on risk factors and disease progression. Overweight and obesity emerged as one of the major risk factors for developing severe COVID-19. Here we review the biology of coronavirus infections in relation to obesity. In particular, we review literature about the impact of adiposity-related systemic inflammation on the COVID-19 disease severity, involving cytokine, chemokine, leptin, and growth hormone signaling, and we discuss the involvement of hyperactivation of the renin-angiotensin-aldosterone system (RAAS). Due to the sheer number of publications on COVID-19, we cannot be completed, and therefore, we apologize for all the publications that we do not cite.
Keyphrases
- sars cov
- coronavirus disease
- respiratory syndrome coronavirus
- healthcare
- insulin resistance
- risk factors
- type diabetes
- weight loss
- growth hormone
- weight gain
- systematic review
- end stage renal disease
- newly diagnosed
- angiotensin ii
- high fat diet induced
- skeletal muscle
- physical activity
- early onset
- social media
- health information
- health insurance