Preclinical Development and Evaluation of Allogeneic CAR T Cells Targeting CD70 for the Treatment of Renal Cell Carcinoma.
Siler H PanowskiSurabhi SrinivasanNguyen TanSilvia K Tacheva-GrigorovaBryan SmithYvonne S L MakHongxiu NingJonathan VillanuevaDinali WijewarnasuriyaShanshan LangZea MeltonAdit GhoshMathilde DusseauxRoman GalettoJonathan R HeyenTao SaiThomas J Van BlarcomJavier Chaparro-RiggersBarbra Johnson SasuPublished in: Cancer research (2022)
These findings demonstrate the efficacy and safety of fratricide-resistant, allogeneic anti-CD70 CAR T cells targeting renal cell carcinoma and the impact of CAR epitope on functional activity. See related commentary by Adotévi and Galaine, p. 2517.