Co-localization of the sodium-glucose co-transporter-2 channel (SGLT-2) with endothelin ETA and ETB receptors in human cardiorenal tissue.

Thomas L WilliamsRhoda E KucAnna L PatersonGeorge R AbrahamAnna L PullingerJanet J MaguireSanjay SinhaPeter J GreasleyPhilip AmberyAnthony P Davenport

Published in: Bioscience reports (2024)

Whether low levels of SGLT-2 have a (patho)physiological role in cardiomyocytes is not known but results suggest the effect of direct blockade of sodium (and glucose) influx via SGLT-2 inhibition in cardiomyocytes should be explored, with potential for additive effects with ETA antagonists.

Keyphrases

endothelial cells
high glucose
induced pluripotent stem cells
type diabetes
blood pressure
metabolic syndrome
human health
skeletal muscle
insulin resistance