Assessment of the nlmixr R package for population pharmacokinetic modeling: A metformin case study.

Wen Yao Mak Qing-Xi OoiCintia Valeria CruzIrene LooiKah Hay YuenJoseph F Standing

Published in: British journal of clinical pharmacology (2022)

nlmixr is reliable for NLMEM. SAEM was superior to FOCEi in terms of bias and precision, and more robust against initial estimate perturbations.

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