Double Trouble: Concomitant RB1 and BRCA2 Depletion Evokes Aggressive Phenotypes.

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Coordinate single- or two copy loss of the BRCA2/RB1 tumor suppressor genes, which reside in close chromosomal proximity, were found to be associated with aggressive prostate cancer and therapeutic resistance. Modeling these events and analyses of human cancers suggest that dual depletion of BRCA2/RB1 may represent a distinct subtype of disease.See related article by Chakraborty et al., p. 2047.

Keyphrases

prostate cancer
breast cancer risk
endothelial cells
radical prostatectomy
genome wide
induced pluripotent stem cells
young adults
transcription factor
genome wide analysis