Regulation of the MCHergic Neural Circuit to Dorsal Raphe Nucleus on Emotion-Related Behaviors and Intestinal Dysfunction in Mice Model of Irritable Bowel Syndrome with Diarrhea.

Xing MingShengli GaoJinqiu SunNana ZhangRuixiao GuoXufei FengXinchi LuanHan XingYang JiaoFeifei Guo

Published in: Neuroendocrinology (2024)

This study suggests that the activation of MCH neurons in the LHA may induce IBS-D symptoms via the DRN and that the MCH receptor antagonist could potentially have therapeutic effects.

Keyphrases

irritable bowel syndrome
spinal cord
neuropathic pain
oxidative stress
depressive symptoms
high fat diet induced
type diabetes
spinal cord injury
insulin resistance
skeletal muscle
adipose tissue
wild type
borderline personality disorder