Nano-curcumin safely prevents streptozotocin-induced inflammation and apoptosis in pancreatic beta cells for effective management of Type 1 diabetes mellitus.
Raghu GanugulaMeenakshi AroraPatcharawalai JaisamutRuedeekorn WiwattanapatapeeHeather G JørgensenVinod P VenkatpurwarBeiyan ZhouAline Rodrigues HoffmannRita BasuShaodong GuoNaga Venkata Ravi Kumar MajetiPublished in: British journal of pharmacology (2017)
Together, these data indicate a potentially translatable dose of nCUR that is safe and efficacious in improving beta cell function, which could prevent T1DM.
Keyphrases
- diabetic rats
- oxidative stress
- induced apoptosis
- cell cycle arrest
- cell death
- endoplasmic reticulum stress
- pi k akt
- high fat diet
- high glucose
- big data
- electronic health record
- mouse model
- machine learning
- signaling pathway
- type diabetes
- diabetic nephropathy
- metabolic syndrome
- drug induced
- insulin resistance
- skeletal muscle