An International Perspective on Preceding Infections in Guillain-Barré Syndrome: The IGOS-1000 Cohort.
Sonja E LeonhardAnnemiek A van der EijkHenning AndersenGiovanni AntoniniSamuel ArendsShahram AttarianFabio A BarrosoKathleen J BatemanManou R BatstraLuana BenedettiBianca van den BergPeter Van den BerghJan BürmannMark BusbyCarlos CasasnovasDavid R CornblathAmy DavidsonAlex Y DoetsPieter A van DoornCharlotte Dornonville de la CourThomas E FeasbyJanev FehmiTania Garcia-SobrinoJonathan M GoldsteinKenneth C GorsonVolkan GranitRobert D M HaddenThomas HarboHans-Peter HartungMd Imran HasanJakob V HolbechJames K L HoltIsrat JahanZhahirul IslamSummer KarafiathHans D KatzbergRuud P KleywegNoah KolbKrista KuitwaardMotoi KuwaharaSusumu KusunokiLinda W G LuijtenSatoshi KuwabaraEdward Lee PanHelmar C LehmannMarijke MaasLorena Martín-AguilarJames A L MillerQuazi Deen MohammadSoledad MongesVelina Nedkova-HristovaEduardo Nobile-OrazioJulio PardoYann PereonLuis Antonio QuerolRicardo ReisinWouter Van RijsSimon RinaldiRhys C RobertsJoyce RoodbolNortina ShahrizailaSøren Hein SindrupBeth SteinTan Cheng-YinHatice TankisiAnne P Tio-GillenMaría J Sedano TousChristine VerboonFrederique H VermeijLeo H VisserRuth HuizingaHugh J WillisonBart C Jacobsnull nullPublished in: Neurology (2022)
Across geographical regions, the distribution of infections was similar, but the association between infection and clinical phenotype differed. A mismatch between symptom reporting and serologic results and the high frequency of coinfections demonstrate the importance of broad serologic testing in identifying the most likely infectious trigger. The association between infections and outcome indicates their value for future prognostic models.