The effects of coagulation factors and their inhibitors on proliferation and migration in colorectal cancer.

Peter Adam ReesJohn CastleHamish William CloustonRebecca LambUrvashi SinghSarah Elizabeth DuffCliona Clare Kirwan

Published in: Cancer medicine (2023)

Thrombin, FXa and TF all increase migration in CRC in vitro. Thrombin induced increase in proliferation is abrogated by dabigatran. Dabigatran may have potential as an anti-cancer therapy in CRC.

Keyphrases

cancer therapy
atrial fibrillation
drug delivery
high glucose
diabetic rats
signaling pathway
drug induced
endothelial cells
risk assessment
stress induced