Effect of platelet-rich plasma on healing of autologous graft after anterior cruciate ligament reconstruction: a randomized control trial.
Kishor MundeSumit BanerjeeNitesh GahlotAbhay ElhenceSaptarshi MandalTaruna YadavPublished in: Regenerative medicine (2023)
Aim: This study aimed to assess the effect of platelet-rich plasma (PRP) on anterior cruciate ligament (ACL) graft healing at graft tunnel interface and ACL graft 6 months post-reconstruction. Material & methods: A randomized trial involving 87 patients was conducted, dividing them into PRP and non-PRP groups. Magnetic resonance imaging (MRI) and functional outcome measures were used to evaluate graft healing. Results: Out of the 87 patients, 80 were analyzed. The PRP group exhibited superior clinical and radiological outcomes compared with the non-PRP group, as indicated by Figueroas score, Lysholm score and knee range of motion. Conclusion: These findings demonstrate that PRP can be used as an adjunct therapy for ACL reconstruction, enhancing graft healing and improving patient outcomes. CTRI approval (Reg. No - CTRI/2018/11/016263).
Keyphrases
- platelet rich plasma
- magnetic resonance imaging
- end stage renal disease
- anterior cruciate ligament reconstruction
- ejection fraction
- newly diagnosed
- chronic kidney disease
- computed tomography
- anterior cruciate ligament
- prognostic factors
- peritoneal dialysis
- type diabetes
- total knee arthroplasty
- patient reported outcomes
- stem cells
- contrast enhanced
- high resolution
- skeletal muscle
- diffusion weighted imaging
- patient reported