Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing.

Anna J StevensonDaniel L McCartneySarah E HarrisAdele M TaylorPaul RedmondJohn M StarrQian ZhangAllan F McRaeNaomi R WrayTara L Spires-JonesBarry W McCollAndrew M McIntoshIan J DearyRiccardo E Marioni

Published in: Clinical epigenetics (2018)

We found a divergent relationship between inflammation and immune system parameters in older age. We additionally report the Hannum measure of epigenetic age acceleration associated with an elevated inflammatory profile cross-sectionally, but not longitudinally.

Keyphrases

oxidative stress
dna methylation
gene expression
physical activity
middle aged
community dwelling