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Dual action of a tyrosinase-mesoporous silica nanoparticle complex for synergistic tissue adhesion.

Su-Hwan KimKwangsoo ShinByung Gee KimNathaniel S HwangTaeghwan Hyeon
Published in: Chemical communications (Cambridge, England) (2022)
Bridging biological tissues for immediate adhesion and long-term sustainability was accomplished using a combination of mesoporous silica nanoparticles (MSNs) and tyrosinase. Tyrosinase-loaded MSNs provided rapid physical adsorption, while tyrosinase within MSNs induced enzymatic chemical bond gluing of tissues. This synergistic strategy has robust potential in tissue adhesives for clinical settings.
Keyphrases
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