Cellular Prion Protein Mediates α-Synuclein Uptake, Localization, and Toxicity In Vitro and In Vivo.

Tobias ThomMatthias SchmitzAnna-Lisa FischerAngela CorreiaSusana CorreiaFranc LlorensAnna-Villar PiqueWiebke MöbiusRenato DominguesSaima ZafarErik StoopsChristopher J SilvaAndre FischerTiago F OuteiroInga Zerr

Published in: Movement disorders : official journal of the Movement Disorder Society (2021)

PrPC 's native trafficking can be misused to internalize misfolded aSyn through a clathrin-based mechanism, which may facilitate the spreading of pathological aSyn. Disruption of aSyn-PrPC binding is, therefore, an appealing therapeutic target in α-synucleinopathies. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

binding protein
oxidative stress
protein protein
amino acid
dna binding
systematic review
small molecule
transcription factor