Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade.

Erica AcquaroneElentina K ArgyrousiManon van den BergWalter GulisanoMauro FàAgnieszka StaniszewskiElisa CalcagnoElisa ZuccarelloLuciano D'AdamioShi-Xian DengDaniela PuzzoOttavio ArancioJole Fiorito

Published in: Molecular neurodegeneration (2019)

Up-regulation of CREB activation through agents acting on the NO cascade might be beneficial against tau-induced synaptic and memory dysfunctions.

Keyphrases

nitric oxide
working memory
cerebrospinal fluid
prefrontal cortex
high glucose
diabetic rats
oxidative stress
hydrogen peroxide