Y Chromosome Genes May Play Roles in the Development of Neural Rosettes from Human Embryonic Stem Cells.

Farzaneh KhaniSimin NafianSepideh MollamohammadiShiva NematiBahare ShokoohianSeyedeh-Nafiseh Hassani Hossein Baharvand Hamid Reza Soleimanpour-Lichaei Ghasem Hosseini Salekdeh

Published in: Stem cell reviews and reports (2022)

Our results suggest that the RPS4Y1 gene may play a critical role in neurogenesis. Also, the generated transgenic ESC lines can be widely employed in basic and preclinical studies, such as sexual dimorphism of neural and cardiac functions, the development of cancerous and non-cancerous disease models, and drug screening.

Keyphrases

embryonic stem cells
genome wide
endothelial cells
copy number
genome wide identification
left ventricular
mental health
emergency department
gene expression
heart failure
transcription factor
brain injury
adverse drug
blood brain barrier
electronic health record