Functional polymorphisms in the LDLR and pharmacokinetics of Factor VIII concentrates.

Barbara LunghiFrancesco Bernardi Nicola MartinelliSabrina FrusconiAlessio BranchiniSilvia LinariGiovanna MarchettiGiancarlo CastamanMassimo Morfini

Published in: Journal of thrombosis and haemostasis : JTH (2019)

With the limitation of different FVIII concentrates and low number of patients, our data show plausible associations of LDLR polymorphisms with FVIII PK parameters, thus supporting their investigation as candidate functional determinants of FVIII PK.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
electronic health record
patient reported outcomes
patient reported