Electrochemical DNA Biosensors Based on the Intrinsic Topological Insulator BiSbTeSe 2 for Potential Application in HIV Determination.
Yujiu JiangShanshan LiPeng ZhuJinge ZhaoXiaolu XiongYetong WuXu ZhangYongkai LiTinglu SongWende XiaoZhiwei WangJunfeng HanPublished in: ACS applied bio materials (2022)
In this work, we reported a sensitive, label-free electrochemical biosensor based on the intrinsic topological insulator (TI) BiSbTeSe 2 for potential application in the determination of the HIV gene. With strong spin-obit coupling, TIs could have robust surface states with low electronic noise, which might be beneficial for the stable and sensitive electron transport between the electrode and electrolyte interface. Under optimized conditions of the biosensors using BiSbTeSe 2 , the differential pulse voltammetry (DPV) peak currents showed a linear relationship with the logarithm of target DNA concentrations ranging from 1.0 × 10 -13 to 1.0 × 10 -7 M, with a detection limit of 1.07 × 10 -15 M. The sensing assay also displayed good selectivity and stability after storage at 4 °C for 7 days. This work provides an effective way to develop biosensors with topological materials, which have a potential application in the clinical determination and monitoring field.
Keyphrases
- label free
- antiretroviral therapy
- hiv positive
- molecularly imprinted
- hiv infected
- single molecule
- solid phase extraction
- hepatitis c virus
- human immunodeficiency virus
- hiv testing
- circulating tumor
- hiv aids
- cell free
- human health
- men who have sex with men
- gold nanoparticles
- room temperature
- gene expression
- high throughput
- nucleic acid
- density functional theory
- south africa
- climate change
- high resolution
- loop mediated isothermal amplification
- molecular dynamics
- simultaneous determination
- tandem mass spectrometry
- liquid chromatography