Hostile Takeover: Tregs Expand in IFNγ-Rich AML Microenvironment.
Paul Brent FerrellShahram KordastiPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
The unexpected higher level of IFNγ in a subset of patients with acute myeloid leukemia (AML; IFNγhigh) upregulates immunosuppressive genes in mesenchymal stem cells (MSC) and expands regulatory T cells through IDO1 overexpression. IDO1 and IFNG gene expression was positively correlated and required both leukemia cells and MSCs, as IFNγhigh cells were not able to induce Tregs alone. See related article by Corradi et al., p. 3141.
Keyphrases
- acute myeloid leukemia
- dendritic cells
- regulatory t cells
- mesenchymal stem cells
- induced apoptosis
- gene expression
- immune response
- cell cycle arrest
- allogeneic hematopoietic stem cell transplantation
- bone marrow
- stem cells
- umbilical cord
- dna methylation
- cell death
- endoplasmic reticulum stress
- signaling pathway
- oxidative stress
- genome wide