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Inulin Amphiphilic Copolymer-Based Drug Delivery: Unraveling the Structural Features of Graft Constructs.

Carla SardoGiulia AuriemmaCarmela MazzacanoClaudia ConteVirgilio PiccoloTania CiagliaMarta Denel-BobrowskaAgnieszka B OlejniczakDonatella FioreMaria Chiara ProtoPatrizia GazzerroRita Patrizia Aquino
Published in: Pharmaceutics (2024)
In this study, the structural attributes of nanoparticles obtained by a renewable and non-immunogenic "inulinated" analog of the "pegylated" PLA (PEG-PLA) were examined, together with the potential of these novel nanocarriers in delivering poorly water-soluble drugs. Characterization of INU-PLA assemblies, encompassing critical aggregation concentration (CAC), NMR, DLS, LDE, and SEM analyses, was conducted to elucidate the core/shell architecture of the carriers and in vitro cyto- and hemo-compatibility were assayed. The entrapment and in vitro delivery of sorafenib tosylate ( ST ) were also studied. INU-PLA copolymers exhibit distinctive features: (1) Crew-cut aggregates are formed with coronas of 2-4 nm; (2) a threshold surface density of 1 INU/nm 2 triggers a configuration change; (3) INU surface density influences PLA core dynamics, with hydrophilic segment stretching affecting PLA distribution towards the interface. INU-PLA 2 NPs demonstrated an outstanding loading of ST and excellent biological profile, with effective internalization and ST delivery to HepG2 cells, yielding a comparable IC 50 .
Keyphrases
  • drug delivery
  • water soluble
  • magnetic resonance
  • photodynamic therapy
  • high resolution
  • climate change
  • risk assessment
  • human health
  • recombinant human