Alternative lengthening of telomeres in molecular subgroups of paediatric high-grade glioma.

Simone Minasi Caterina Baldi Francesca Gianno Manila Antonelli Anna Maria Buccoliero Torsten Pietsch Maura Massimino Francesca Romana Buttarelli

Published in: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (2020)

Our results show a strong association between H3.3 mutations and ALT, and highlight the different telomeric profiles in histone-defined subgroups: H3.3-G34R mutants always trigger ALT to maintain telomere length, irrespective of ATRX status, whereas only some H3.3-K27M tumours activate ALT. These findings suggest that acquiring the gly34 mutation on H3.3 might suffice to trigger the ALT mechanism.

Keyphrases

high grade
emergency department
intensive care unit
low grade
dna damage
children with cerebral palsy