Acute Fingolimod Effects on Baroreflex and Cardiovascular Autonomic Control in Multiple Sclerosis.
Vittorio RaccaMarco RovarisRosella CavarrettaEmanuele VainiAnastasia ToccafondiMarco Di RienzoPublished in: Journal of central nervous system disease (2019)
Our findings indicate that although the first dose of fingolimod invariably activates the parasympathetic system, in several subjects, it may induce also a surge in the sympathetic cardiac drive. This suggests that not only the vagal, as usually assumed, but also the sympathetic autonomic branch should be considered in the risk profile assessment of MS patients starting treatment with fingolimod.
Keyphrases
- multiple sclerosis
- heart rate variability
- end stage renal disease
- white matter
- heart rate
- chronic kidney disease
- newly diagnosed
- ejection fraction
- peritoneal dialysis
- liver failure
- prognostic factors
- respiratory failure
- left ventricular
- blood pressure
- mass spectrometry
- drug induced
- intensive care unit
- aortic dissection
- mechanical ventilation