Toll-Like Receptor 8 Agonist GS-9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B.
Stephane DaffisScott BalsitisJason ChamberlainJim ZhengRex SantosWilliam RoweDhivya RamakrishnanDivya PattabiramanSandra SpurlockRuth ChuDon KangMichael MishRicardo RamirezLi LiBei LiSarina MaMagdeleine HungChristian VoitenleitnerChangsuek YonManasa SureshStephan MennePaul CoteWilliam E DelaneyRichard MackmanSimon P FletcherPublished in: Hepatology (Baltimore, Md.) (2020)
Finite, short-duration treatment with a clinically relevant dose of GS-9688 is well tolerated and can induce a sustained antiviral response in WHV-infected woodchucks; the identification of a baseline intrahepatic transcriptional signature associated with response to GS-9688 treatment provides insights into the immune mechanisms that mediate this antiviral effect.