Aberrant Activation of Cell-Cycle-Related Kinases and the Potential Therapeutic Impact of PLK1 or CHEK1 Inhibition in Uterine Leiomyosarcoma.
Kosuke YoshidaAkira YokoiTomofumi YamamotoYusuke HayashiJun NakayamaTsuyoshi YokoiHiroshi YoshidaTomoyasu KatoHiroaki KajiyamaYusuke YamamotoPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
We identified upregulated expressions of PLK1 and CHEK1; their kinase activity was activated in uterine leiomyosarcoma. BI-2536 and prexasertib demonstrated a significant anticancer effect. Therefore, cell-cycle-related kinases may present a promising therapeutic strategy for the treatment of uterine leiomyosarcoma.