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Aberrant Activation of Cell-Cycle-Related Kinases and the Potential Therapeutic Impact of PLK1 or CHEK1 Inhibition in Uterine Leiomyosarcoma.

Kosuke YoshidaAkira YokoiTomofumi YamamotoYusuke HayashiJun NakayamaTsuyoshi YokoiHiroshi YoshidaTomoyasu KatoHiroaki KajiyamaYusuke Yamamoto
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
We identified upregulated expressions of PLK1 and CHEK1; their kinase activity was activated in uterine leiomyosarcoma. BI-2536 and prexasertib demonstrated a significant anticancer effect. Therefore, cell-cycle-related kinases may present a promising therapeutic strategy for the treatment of uterine leiomyosarcoma.
Keyphrases
  • cell cycle
  • cell proliferation
  • tyrosine kinase