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The involvement and therapeutic potential of lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway in arsenic trioxide-induced cardiotoxicity.

Xiuyun ShenFengnan ZhiChunpeng ShiJincheng XuYuqiu ChaoJuan XuYanan JiangYunlong BaiBaofeng Yang
Published in: Journal of translational medicine (2023)
The lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway is involved in ATO-induced cardiotoxicity. Propranolol can attenuate ATO-induced cardiotoxicity at least partially through the lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway. Combined administration with propranolol may be a new strategy for alleviating the cardiotoxicity of ATO.
Keyphrases
  • high glucose
  • diabetic rats
  • oxidative stress
  • long non coding rna
  • drug induced
  • ischemia reperfusion injury
  • endothelial cells
  • long noncoding rna
  • drinking water