Elucidation on Predominant Pathways Involved in the Differentiation and Mineralization of Odontoblast-Like Cells by Selective Blockade of Mitogen-Activated Protein Kinases.

Published in: BioMed research international (2018)

Blockade of p38-MAPK signaling pathway resulted in significant inhibition of ALP activity, mineralization, and downregulation of osteogenic markers. The data implicated that p38 signaling pathway plays a critical role in the regulation of MDPC-23 cells differentiation and mineralization.

Keyphrases

signaling pathway
induced apoptosis
pi k akt
cell cycle arrest
epithelial mesenchymal transition
mesenchymal stem cells
endoplasmic reticulum stress
bone marrow
electronic health record
cell proliferation
oxidative stress
big data
cell death
machine learning
artificial intelligence
deep learning