KRT13 promotes stemness and drives metastasis in breast cancer through a plakoglobin/c-Myc signaling pathway.

Lijuan YinQinlong LiStefan MrdenovicGina Chia-Yi ChuBoyang Jason WuHong BuPeng DuanJayoung KimSungyong YouMichael S LewisGangning LiangRuoxiang WangHaiyen E ZhauLeland W K Chung

Published in: Breast cancer research : BCR (2022)

This study reveals that KRT13 promotes breast cancer cell growth and metastasis via a plakoglobin/c-Myc pathway. Our findings reveal a potential novel pathway for therapeutic targeting of breast cancer progression and metastasis.

Keyphrases

signaling pathway
epithelial mesenchymal transition
stem cells
genome wide
pi k akt
cancer therapy
single cell
gene expression
risk assessment
dna methylation
drug delivery
young adults
induced apoptosis