Association of Lower Rostral Anterior Cingulate GABA+ and Dysregulated Cortisol Stress Response With Altered Functional Connectivity in Young Adults With Lifetime Depression: A Multimodal Imaging Investigation of Trait and State Effects.

Maria IronsideJessica M DudaAmelia D MoserLaura M HolsenChun S ZuoFei DuSarah PerloChristine E RichardsXi ChenLisa D NickersonKaylee E NullShiba M EsfandMadeline M AlexanderDavid J CrowleyMeghan LauzeMadhusmita MisraJill M GoldsteinDiego A Pizzagalli

Published in: The American journal of psychiatry (2024)

Lifetime MDD was characterized by reduced rACC GABA+ as well as dysregulated cortisol-related interactions between top-down control (frontoparietal) and threat (task-related) networks. These findings warrant further investigation of the role of GABA in the vulnerability to and treatment of MDD.

Keyphrases

functional connectivity
resting state
major depressive disorder
high resolution
depressive symptoms
climate change
genome wide
sleep quality
middle aged
chronic pain
drug induced
smoking cessation