Transcriptional Patterns of Brain Structural Covariance Network Abnormalities Associated With Suicidal Thoughts and Behaviors in Major Depressive Disorder.
Kun QinHuiru LiHuawei ZhangLi YinBaolin WuNanfang PanTaolin ChenNeil RobertsJohn A SweeneyXiaoqi HuangQiyong GongZhiyun JiaPublished in: Biological psychiatry (2024)
These findings revealed robust brain structural deficits at the network level, highlighting the importance of SCN topological measures in characterizing individual suicidality and demonstrating its linkage to molecular function and cell types, providing novel insights into the neurobiological underpinnings and potential markers for prediction and prevention of suicide.
Keyphrases
- major depressive disorder
- bipolar disorder
- single cell
- resting state
- white matter
- functional connectivity
- depressive symptoms
- traumatic brain injury
- cerebral ischemia
- gene expression
- transcription factor
- cell therapy
- genome wide
- stem cells
- dna methylation
- oxidative stress
- risk assessment
- blood brain barrier
- climate change
- network analysis
- human health