Comparison of three-parameter kinetic model analysis to standard Patlak's analysis in 18F-FDG PET imaging of lung cancer patients.

Eric LaffonM L CalcagniG GalliA GiordanoA CapotostiR MarthanL Indovina

Published in: EJNMMI research (2018)

Comparison between 3P-KMA and Patlak's analysis significantly showed that the latter underestimates Ki because it arbitrarily set kb to zero: the greater the kb value, the greater the Ki underestimation. This underestimation was not revealed when comparing 5P-KMA and Patlak's analysis. We suggest that further studies are warranted to investigate the 3P-KMA efficiency in various tissues showing greater 18F-FDG trapping reversibility than lung cancer lesions.

Keyphrases

pet imaging
gene expression
squamous cell carcinoma
neoadjuvant chemotherapy
lymph node
single cell
locally advanced
data analysis