The radiation- and chemo-sensitizing capacity of diclofenac can be predicted by a decreased lactate metabolism and stress response.

Melissa SchwabAli Bashiri DezfouliMohammad KhosraviBayan AlkotubLisa BauerMohammad Javed Tahmasebi BirganiGabriele Multhoff

Published in: Radiation oncology (London, England) (2024)

These findings suggest that a decrease in the LDH activity and/or stress response upon diclofenac treatment predicts its radiation/chemo-sensitizing capacity.

Keyphrases

photodynamic therapy
combination therapy
cancer therapy
locally advanced
radiation induced
squamous cell carcinoma
radiation therapy
drug delivery